CanDo on-lattice submissions are online. We require all users to re-register due to a new licensing agreement.

This submission page enables the prediction of the 3D equilibrium structure of programmed DNA assemblies that are designed to reside on a honeycomb [3] or square [5] lattice using the drawing programĀ caDNAno [6]. The caDNAno file preparation, input, and CanDo finite element modeling procedure is demonstrated in thisĀ tutorial.

Users of this submission link are kindly requested to cite the following references:

  • DN Kim, F Kilchherr, H Dietz, M Bathe. Quantitative prediction of 3D solution shape and flexibility of nucleic acid nanostructures. Nucleic Acids Research, 40(7):2862-2868 (2012). [ Pubmed Article ]
  • CE Castro, F Kilchherr, DN Kim, EL Shiao, T Wauer, P Wortmann, M Bathe, H Dietz. A primer to scaffolded DNA origami. Nature Methods, 8: 221-229 (2011). [ Pubmed Article ]